Chronic fatigue

What is chronic fatigue?

Chronic fatigue, also known as myalgic encephalomyelitis (ME) or systemic exertion intolerance disease (SEID), is a complex and serious long-term illness characterized by extreme and persistent fatigue that is not improved by rest. The fatigue worsens with physical or mental activity, but doesn't improve with sleep or rest.

Symptoms include:

Causes

The exact causes of ME/CFS are unknown at this time. Potential factors may include:

Diagnosis

There are no laboratory tests or biomarkers available for ME/CFS. Diagnosis relies on a thorough clinical evaluation to rule out other fatigue-causing conditions.

The key diagnostic criteria are:


  1. Severe, persistent fatigue lasting over 6 months not due to overexertion or other medical conditions

  2. Post-exertional malaise

  3. Unrefreshing sleep

  4. Either cognitive dysfunction OR orthostatic intolerance

Treatment

While there is no cure for ME/CFS, symptom management can help relieve suffering. Key treatments include:

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